I'm a full stack developer not bound to one technology stack. I love technical challenges and am interested in all parts of development: analysis, architecture, coding, testing, deployment, ...
In theory you can run any node application this way. I only know React as a client-side framework and I don't have any experience running it on the server. It's hard to give a solution just via a comment but if React should run on the server as well I would create a separate site in IIS for the ASP.Net API project and another site for the React application. That way the API project can run via IIS and the React application uses IIS as a reverse proxy to the node webserver. If you can give more information how the different applications work I might be able to help further.
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Hello Eduardo,
In theory you can run any node application this way. I only know React as a client-side framework and I don't have any experience running it on the server. It's hard to give a solution just via a comment but if React should run on the server as well I would create a separate site in IIS for the ASP.Net API project and another site for the React application. That way the API project can run via IIS and the React application uses IIS as a reverse proxy to the node webserver. If you can give more information how the different applications work I might be able to help further.