I say no. They only way to do that is by being 100% compatible, and as far as I know that's not a goal for Deno.
Another thing, the size of node's ecosystem is too big to be replaced. The internet told me years ago that node was going to "kill" PHP and yet here we are. PHP is still out there.
I agree, the size of the ecosystem is far too large to suddenly change now. It took forever for even basic hosting platforms to support NodeJS. I expect it will be a while before Deno really gets adopted as well.
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