If you're looking for a sort of "everything in a box" approach, I think Sails, Loopback, and Kraken are kind of top of the heap. If you're looking for a bit more flexibility, Hapi (from Walmart Labs, which powers Walmart mobile I think) is great. On an even more granular level, there's Koa and Express (I recommend Koa over express these days, since its api is based on Promises instead of callbacks, which is nice). With either any of the latter, you'd need to figure out your own ways of working with databases (Bookshelf + Knex is popular), and probably a bunch of other pieces that don't come included.
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