Concept: Shift from linear DNA editing to 3D-Graph Synchronization.
1. The Core Logic
Genome = Hardware. 3D-topology (chromatin folding) determines logic execution.
Technical Debt: Mutations are "bugs". Instead of patching code (CRISPR), we stabilize the Infrastructure.
2. Invariant Nodes (Master Hubs)
We identify Topological Invariants—immutable 3D-nodes that act as system anchors.
State Equation:
$$\Omega_i = \lim_{\Delta t \to \infty} \sum_{j=1}^{n} \oint_{\gamma} \frac{\partial \Phi_j}{\partial x} ds$$
If $\Omega_i$ is stable, the system is self-healing.
3. Implementation (Synchronization)
Scan: Map Hi-C data to find invariant hubs.
Model: Define the "Golden State" (Dynamic Homeostasis).
Align: Use resonance to nudge topology back to its Invariant Constraints.
Bottom Line: Declarative vs Imperative. We don't fix bits; we restore the System Architecture.
https://x.com/AleksejGor40999/status/2010295524419944884?s=20
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