I purposefully didn't mention CSS frameworks for multiple reasons:
They may be easy to add initially, but you still hit a steep learning curve when you go to customize.
You have to check the styles and customize immediately because they are often not accessible.
A class per declaration quickly becomes a lot to replicate on every element. A big point I'm making is that you want to reuse one clearly named class that is easy to understand when you come back to the project in 6 months.
I personally find the inline styling harder to read.
I don't have any advice for using them because I don't use them.
I didn't want to debate CSS framework fans in the comments of this blog.
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I purposefully didn't mention CSS frameworks for multiple reasons: