Youtube, google search, facebook, and smbc-comics.com all misbehave if you increase your system font size on mac, on multiple browsers. Usually it's just having to scroll to the right a little to see everything. Sometimes stuff just gets cut off. Smbc's advertising experience is a bit crappy in general, and on mobile often does shitty things that redirect you to the app store. However, it's a great comic and if I need to kill some time, I can keep myself occupied for a while hitting the "random" button.
Reddit's redesign is ugly (and has the same aforementioned system font issue), so I keep it in legacy mode.
Twitter is pretty well-behaved, except I don't know how their images are supposed to be usable. Vertical memes are especially bad in firefox without pinch-to-zoom.
LinkedIn makes me want to tear my eyeballs out every time I visit it. I'm not sure what it is, but it feels like it's screaming at me.
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