I'm of the "one monitor to rule them all" persuasion. I like to have everything directly in front of me, so I don't have to turn my head to do something. I've found that constantly looking off to the side causes me neck pain, so I prefer the 1 large monitor with what I'm working on front and center.
Usually that's a giant terminal window that takes up the whole screen, split into panes with tmux. Sometimes I'll also do columns with a browser and a terminal next to each other.
I try to minimize distractions, so chat and email are in the background with notifications disabled. I check them at specific times during the day and that's it.
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