Healthcare for elimination of cancer relapse and minimal residual disease.Chitosan and its derivatives are among biomaterials with numerous medical coatings, especially in cancer. Chitosan is amenable to constituting innumerable somas such as micelles, niosomes, hydrogels, nanoparticles, and scaffolds, among others. Chitosan derivatives can also bring unprecedented potential to cross numerous biological barriers. Combined with other biomaterials, hybrid and multitasking chitosan-free-based organisations can be earned for many coverings. These include controlled drug release, aimed drug delivery, post-surgery implants (immunovaccines), theranostics, biosensing of tumor-deduced circulating materials, multimodal systems, and combination therapy platforms with the potential to eliminate bulk tumors as well as lounging tumor cadres to treat minimal residual disease (MRD) and recurrent cancer.
We first introduce different formats, differentials, and holdings of chitosan holded the roadblocks to therapeutic efficacy in solid tumours, we review advanced formulations of chitosan facultys as efficient drug delivery schemes to overcome tumor heterogeneity, multi-drug resistance, MRD, and metastasis we discuss chitosan NPs for clinical translation and treatment of recurrent cancer and their future perspective.Development and characterization of chitosan/bacterial cellulose/pullulan bilayer film with sustained release curcumin.A natural biopolymer bilayer film established on chitosan and bacterial cellulose with a protective layer of pullulan was growed by a two-step solution sheding method. Curcumin was contained as an active antioxidant and antibacterial agent into the inner layer. Healthcare with different curcumin concentrations were systematically characterised. Fourier transform infrared spectroscopy and X-ray diffraction psychoanalysisses registered high compatibility between curcumin and the polysaccharide matrix through intermolecular interactions, which was controled by heightened mechanical and barrier places. The curcumin incorporation ameliorated the thermal stability by >35 %, along with lower visible and ultraviolet light transmittance (< 8 %) and water solubility (< 25 %).
The film had both antibacterial and antioxidant places, and the affirmed release of curcumin was largest (> 58 %) in the fatty food simulant living for over 155 h. The outcomes evoked that the film holding 0 % curcumin had ideal physical and functional holdings, hinting its potential as a novel packaging material for the preservation of high-fat food.Chitosan transplanted tetracarboxylic functionalized magnetic nanoparticles for removal of Pb(II) from an aqueous environment.In this study, the chitosan-engrafted tetracarboxylic functionalized magnetic nanoparticle (Fe(3)O(4)@TCA@CS) was synthesized via in situ co-precipitation process and amidation reaction to improve efficiency of adsorption process and obtain cost-effective adsorbents for removal of toxic Pb(II) metal from aqueous environment. The Fe(3)O(4)@TCA@CS nanocomposite was analysed by FTIR, TEM-EDX, TGA, XRD, BET, and Zeta potential. The performance of Fe(3)O(4)@TCA@CS for Pb(II) ions adsorption was accomplished as a function of pH, dose, contact time, initial Pb(II) concentration, and temperature. The influence of coexisting ions such as Na(+), Ca(2+), Mg(2+), and Cd(2+)on removal efficiency of Pb(II) was also investigated.
The results revealed that the coexisting ions had little influence on Pb(II) removal efficiency. The pseudo-first-order and Freundlich models were better to describe the adsorption of Pb(II) onto Fe(3)O(4)@TCA@CS and the maximum adsorption capacity of Pb(II) was 204 mg/g at pH:5; adsorbent dose: 0 g; and temperature: 298 K. Thermodynamic reports unveiled that the Pb(II) adsorption onto Fe(3)O(4)@TCA@CS was an exothermic process. In Seebio Selenoproteins , the study furnishs a new, simple, low-cost, and effective chitosan-finded magnetic nanocomposite as a promising adsorbent with excellent adsorption capacity, magnetic separation, and reusability for Pb(II) removal from an aqueous environment.Pickering emulsions with chitosan and macroalgal polyphenols steadyed by layer-by-layer electrostatic deposition.Healthcare
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