honcho and django-environ would pair well together! If you don't want your code to call environ.Env.read_env() to read an .env file, then honcho could do that for you by loading all the environment variables from an .env file before your web server even starts up.
For my latest project, I'm deploying with Heroku so, instead of honcho, I'm using heroku local which behaves in a very similar way.
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