In modern pharmaceutical manufacturing, the development of complex APIs (Active Pharmaceutical Ingredients) demands high-purity and reliable chemical intermediates. One such essential compound is 2,4-Dichloropyrimidine, which plays a pivotal role in the synthesis of Pazopanib, a widely used anti-cancer drug.
Understanding 2,4-Dichloropyrimidine
2,4-Dichloropyrimidine is a pyrimidine derivative with the molecular formula C4H2Cl2N2. It features two chlorine atoms positioned at the 2nd and 4th carbon atoms of the pyrimidine ring, making it a versatile intermediate in pharmaceutical and agrochemical synthesis.
Due to its reactive nature and structural compatibility, this compound is commonly used in the development of kinase inhibitors, particularly Pazopanib, which is approved for treating renal cell carcinoma and soft tissue sarcoma.
Role in Pazopanib Synthesis
Pazopanib is a tyrosine kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), and c-Kit, helping to block tumor angiogenesis. The synthesis process of Pazopanib involves multiple steps, with 2,4-Dichloropyrimidine being a key intermediate in constructing the drug’s core structure.
Using this intermediate helps ensure:
Enhanced chemical stability
Better reaction yield
High purity of the final API
Compatibility with large-scale production
Vidgastech – Reliable Supplier of Pharmaceutical Intermediates
Vidgastech is a leading manufacturer and global supplier of pharmaceutical intermediates, including 2,4-Dichloropyrimidine. We provide consistent quality, batch-to-batch purity, and scalable solutions for pharmaceutical R&D and production.
Our key strengths include:
✅ GMP-compliant production facilities
✅ Strict quality assurance processes
✅ Competitive pricing for bulk quantities
✅ On-time delivery worldwide
✅ Complete regulatory and technical documentation
Applications Beyond Pazopanib
While Pazopanib is a primary application, 2,4-Dichloropyrimidine is also used in:
Other kinase inhibitors
Antiviral and anti-inflammatory compounds
Research in pyrimidine-based drug discovery
Fine chemicals and specialty intermediates
Conclusion
In the landscape of oncology drug development, 2,4-Dichloropyrimidine continues to be a foundational compound, enabling the synthesis of powerful therapies like Pazopanib. As pharmaceutical research advances, the demand for high-quality intermediates grows—making Vidgastech a trusted partner for companies around the world.
🔗 To learn more or request a quote, visit:
👉 www.vidgastech.com
Top comments (0)