You can make desktop apps with Python. One of the ways to do that is to use PyQt, a very professional building block.
PyQt gives you designer, you can design what your windows should look like simply with drag and drop.
Then you can load the designs in Python. Link it all together using PyQt.
Many applications are made with Qt (PyQt), including the whole KDE desktop environment. You can make any desktop app you want, run it on all popular platforms (Windows, Mac OS X, Linux).
Why not learn PyQt?
Does it sound more easy than you think it is?
Check out tutorial below for an easy start. It comes with an 1 hour video and over 80 examples.