Your code is going to face someone eventually and they need to interact with it. What framework do you use and why? Do you use something like Cordova to go multi-platform?
Or, do you just go Native for the platform?
Bonus What operating system or web technology is your brain running on?
Edit: We live in a mobile world, so chances are, your application will run on a phone. Many are using the hybrid approach of using web technologies + native interfacing vs. native code. If you're using web technologies, what framework do you pick? Or, do you just go native?