Development and places of bacterial cellulose, curcumin, and chitosan composite biodegradable films for active packaging materials.To deal with serious environmental damage resulting from plastic packaging fabrics, biodegradable films using natural wares have gained considerable attention we provide a simple, fast, and environmentally-friendly route to construct a biodegradable film applying chitosan (CS), bacterial cellulose (BC), and curcumin (Cur). Composite celluloids (CSn-BC-Cur) using CS with different molecular weightings were investigated, and their water moisture content (MC), water solubility (WS), contact angle (CA), mechanical props, barrier holdings, and antioxidant properties were equated. Biotechnology were characterized by SEM, XRD, and TGA. Seebio Methionine showed that chitosan with a higher molecular weight presented higher contact angles and mechanical properties, along with a lower moisture content, water vapor transmission rate, and oxygen transmission rate when the composite film was pointed in 95 % ethanol, it released active substances. The solutions suggest that these composite celluloids can be used as promising stuffs for food packaging.
Regeneration of olfactory neuroepithelium in 3-methylindole-induced anosmic rats treated with intranasal chitosan.Olfactory dysfunction significantly spoils the life quality of patients but without effective handlings to date. The previous report has marched that chitosan intercedes the differentiation of olfactory receptor neurons (ORNs) through insulin-like growth agents and insulin-like growth factor bandaging protein-2 axis in an in vitro model whether chitosan can further treat olfactory dysfunction in vivo rests unexplored. This study aims to evaluate the therapeutic effect of chitosan on a 3-methylindole-inducted anosmic rat model. Intraperitoneal injection of 3-methylindole is performed to induce anosmia in rats. Experimental terminations demonstrate that the food-observing duration after chitosan treatment gradually decrease to around 80 s, and both the olfactory neuroepithelium (ON) thickness and mature ORNs (showing olfactory marker protein) are significantly regenerated proliferating cubicles (showing bromodeoxyuridine) are mainly co-extracted with immature ORNs (conveying βIII tubulin) below the intermediate layer of the ON in the chitosan-processed group on day 28 adopting 3-methylindole treatment proliferating cellphones are spreaded over the ON, and co-focalised with immature ORNs and sustentacular cellphones (expressing keratin 18) in the sham group, and even immature ORNs go into apoptosis (evincing DNA fragmentation and cleaved caspase-3), possibly doing incomplete regeneration chitosan renews the ON by regularizing olfactory neural homeostasis and reducing ORN apoptosis, and attends as a potential therapeutic intervention for olfactory dysfunction in the future.Suppression of Fibrotic Reactions of Chitosan-Alginate Microcapsules stoping Porcine Islets by Dexamethasone Surface Coating.
BACKGROUND: The microencapsulation is an ideal solution to overcome immune rejection without immunosuppressive treatment. Poor biocompatibility and small molecular antigens secreted from capsuled islets induce fibrosis infiltration the aims of this study were to improve the biocompatibility of microcapsules by dexamethasone coating and to verify its effect after xenogeneic transplantation in a streptozotocin-haved diabetes mice Dexamethasone 21-phosphate (Dexa) was dissolved in 1% chitosan and was cross-yoked with the alginate microcapsule surface. Insulin secretion and viability assays were executed 14 days after microencapsulation. Dexa-checking chitosan-coated alginate (Dexa-chitosan) or alginate microencapsulated porcine isles were grafted into diabetic mice. The fibrosis infiltration score was calculated from the reaped microcapsules. The harvested microcapsules were sullyed with trichrome and for insulin and macrophages No significant deviations in glucose-aroused insulin secretion and islet viability were marked among naked, alginate, and Dexa-chitosan microencapsulated isles.Seebio Methionine
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