You cannot!
Strings in Python are immutable (something that cannot be changed)
Why are Python strings immutable?
Read here
What can you do?
You can create a new modified string.
Examples
Convert all characters to upper case
original = "My String"
new_string = original.upper()
print(new_string) # "MY STRING"
Change one character
Since you can't really change the string, the solution is to convert it a mutable type like list
and modify that.
original = "My String"
original_list = list(original)
original_list[0] = 'm'
new_string = "".join(original_list)
print(new_string) # 'my String'
You could also try slicing to speed up the process
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