We're using confluence with a template page hierarchy. Something like:
Getting started with <Project>
<Project> Processes and Procedures
<Project> Architecture and domain
<Project> Active Development Projects
<Project> Staff and Organization
The latest version of Confluence lets you copy the whole page hierarchy and do a find/replace in the title of the pages.
I'm not sure if Confluence counts as a 'large-ish setup'. It requires a database, and it is a java webapp, with all the infrastructure that implies. It hasn't been too bad for our team, though. On the positive side, it gives you a wysiwyg editor
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