First of all which type of website you want to develop, static or dynamic?
If you want to develop a static website than bootstrap (as bootstrap is only for styling) and flask is good choice.
You can also you the same to develop the dynamic websites which can have a flask API (as backend) and bootstrap and HTML for front end.
Also if you have some idea of JavaScript than you can try either react or angular as well, but it will require some learning.
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First of all which type of website you want to develop, static or dynamic?
If you want to develop a static website than bootstrap (as bootstrap is only for styling) and flask is good choice.
You can also you the same to develop the dynamic websites which can have a flask API (as backend) and bootstrap and HTML for front end.
Also if you have some idea of JavaScript than you can try either react or angular as well, but it will require some learning.