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A large number of microbes exist in the gut and they have the ability to process and utilize ingested food. It has been reported that their products are involved in colorectal cancer development. The molecular mechanisms which underlie the relationship between gut microbial products and CRC are still not fully understood. The role of some microbial products in CRC is particularly controversial. Elucidating the effects of gut microbiota products on CRC and their possible mechanisms is vital for CRC prevention and treatment. In this review, recent studies are examined in order to describe the contribution metabolites and toxicants which are produced by gut microbes make to CRC, primarily focusing on the involved molecular mechanisms.Abbreviations CRC colorectal cancer; SCFAs short chain fatty acids; HDAC histone deacetylase; TCA cycle tricarboxylic acid cycle; CoA cytosolic acyl coenzyme A; SCAD short chain acyl CoA dehydrogenase; HDAC histone deacetylase; MiR-92a microRNA-92a; KLF4 kruppel-like factor; PTEN phlavin-containing monooxygenase 3; H2S Hydrogen sulfide; SRB sulfate-reducing bacteria; IBDs inflammatory bowel diseases; NSAID non-steroidal anti-inflammatory drugs; BFT fragile bacteroides toxin; ETBF enterotoxigenic fragile bacteroides; E-cadherin extracellular domain of intercellular adhesive protein; CEC colonic epithelial cells; SMOX spermine oxidase; SMO smoothened; Stat3 signal transducer and activator of transcription 3; Th17 T helper cell 17; IL17 interleukin 17; AA amino acid; TCF transcription factor; CDT cytolethal distending toxin; PD-L1 programmed cell death 1 ligand 1.Breastfeeding has many known benefits, but rates vary globally. We propose two main reasons why psychological theory and interventions have not been successful to date in explaining breastfeeding behaviours. Specifically, prior research underestimates the importance of (1) specific emotions and (2) wider injunctive influences (i.e., societal and moral norms about what women feel they ought to be doing) in the breastfeeding experience. Therefore, we conducted a systematic review of quantitative, qualitative, and mixed-methods studies that explored whether injunctive norms and/ or specific emotions are associated with breastfeeding behaviours (i.e., intentions, initiation and duration). Seventy-two papers were included in this review; data were extracted and quality appraisals conducted for all included studies. A meta-analysis of effect sizes was performed with the quantitative data. A convergent qualitative synthesis of the data was conducted, resulting in the following line of argument Breastfeeding is a social behaviour and not a personal/individual behaviour. From this line of argument, three themes with associated sub-themes were developed, highlighting the importance of both specific emotions and injunctive norms on breastfeeding behaviours. click here These influences are discussed in relation to both theoretical and practical implications, as well as future research.Foodservice is estimated to produce 12% of the total food waste in Europe, and it is a major target for policies against food waste. The amount of food lost during foodservice operations has been assessed in the literature as a figure ranging from 10% to 41% of the quantity prepared in the kitchen, either as non-served food or as plate waste. In this paper, a systematization of the current initiatives against food waste in EU school foodservice is provided. This background is used as a base to discuss the results of a direct assessment of food waste conducted in 78 primary schools in Italy, where 28.6% of the food prepared was not consumed by the diners. Part of it was saved for reuse, while the rest was disposed and treated as organic waste or, to a lesser extent, as unsorted waste. The flows of food waste, represented by a Sankey diagram, show that some actions may be implemented in order to save more food from disposal; for example, implementing donation programmes for non-served food or using doggy bags to avoid the disposal of plate waste. A greater effort shall be put on preventive actions, aimed at avoiding the generation of food waste; in this sense regular monitoring at schools may act as a first preventive measure as it can increase the awareness of students, teachers and foodservice staff over the issue of food waste.Background There is increasing recognition in medical education that greater emphasis must be placed on preparing graduating medical students for their new roles as interns. Few publications in the literature have described transition-to-residency curricula specifically for students interested in pediatrics or pediatric-related fieldsApproach We developed novel online pediatric cases, embedded within an innovative, hybrid transition-to-residency course, to address high yield, multi-disciplinary topics within the context of several of the AAMC's identified Entrustable Professional ActivitiesEvaluation The pilot cases were evaluated over two academic years (2018, 2019) at a single academic medical center as part of routine student course evaluation (N = 18/35) with the 2019 evaluation containing additional retrospective pre-post survey questions (N = 9/18) assessing self-reported changes in knowledge. Almost all students were very satisfied or satisfied with the modules overall (94%), the quality of the resources provided (100%), and the structure and clarity of the presentation of the material (100%). Among the students who completed the retrospective pre-post survey after participation in the online modules, significant self-reported improvements were noted in writing orders to the pediatrics floor (Z = -2.07, p = 0.04), providing anticipatory guidance (Z = -2.0,p = 0.046), formulating a differential diagnosis for common pediatric conditions (Z = -2.24, P = 0.03), and preparedness for managing common pediatric floor emergencies (Z = -2.33, P = 0.02).Reflection We demonstrated feasibility of implementation of an interactive, online case-based curriculum, medical student satisfaction with content and delivery, and increased self-reported knowledge after completion of the pilot pediatric cases on the online, asynchronous learning platform.click here