The fastest frontend framework is no frontend framework.
It's a bit paradoxical but you can actually make a framework at least a little bit faster than typical vanilla when performing DOM updates, but also significantly faster and more responsive for when you have massive amounts of updates and you start adding schedulers, sync up with animation frames, web worker bridges, etc... all the usual good stuff that if you start adding to a vanilla app, you'd end up calling a framework anyway, in the end. :)
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It's a bit paradoxical but you can actually make a framework at least a little bit faster than typical vanilla when performing DOM updates, but also significantly faster and more responsive for when you have massive amounts of updates and you start adding schedulers, sync up with animation frames, web worker bridges, etc... all the usual good stuff that if you start adding to a vanilla app, you'd end up calling a framework anyway, in the end. :)