In type 2 diabetes mellitus (T2DM), hyperglycemia leads to oxidative insult. Vitamins A and E have antioxidant potentials and may help in managing diabetes. The combined effect of high-dose vitamin A plus E supplementation with and without zinc on T2DM, has never been examined. Thus, this study aimed to evaluate and compare the effect of high-dose vitamin A plus E supplementation (AE) versus high-dose vitamin A plus E with zinc (AEZ), on different diabetic parameters. Ninety-eight patients with T2DM were randomized to receive either 50,000 IU vitamin A and 100 mg vitamin E (AE group, N = 36), an equivalent dose of vitamin A and E combined with 25 mg zinc (AEZ group, N = 35), or no supplements (control group, N = 27) for three months. Compared to control, AEZ group showed significant reductions in fasting blood glucose, 2 h postprandial blood glucose, and glycated hemoglobin (HbA1c) with significant increases in homeostasis model assessment of beta-cell function and difference value of fasting insulin. Two hair loss cases were recorded in both treated groups. Although vitamin A needs dose moderation, these results suggest that, high-dose vitamin A plus E supplementation combined with zinc may improve glycemic control, β-cell function, and insulin secretion in adults with T2DM.
Developed a detailed finite element model of spine and validated with the experimental or cadaveric tests to gain insight on occupant safety.
This study evaluates the influence of occupant collision state parameters such as height of the drop, occupant seating posture (occupant posture angle) and mass of the upper body on the risk of lumbar spinal injury during a frontal crash.
This parametric evaluation utilizing response surface methodology (RSM) performed. ANOVA was used to test the significance of parameters.
Higher axial force of 3547 N is observed with higher dropping distance of 1500 mm. Similarly, higher strain and energy absorption were observed for the same dropping condition respectively.
The result shows that all the factors considered in the experiment contribute to the risk of spinal lumbar injury during the frontal crash. Among all, height of the drop and the occupant posture angle are the most significant parameters in determining the lumbar spinal injury of occupant. Veliparib supplier It is observed that the injury criteria are directly proportional to the posture angle of the seat and height of drop.
The result shows that all the factors considered in the experiment contribute to the risk of spinal lumbar injury during the frontal crash. Among all, height of the drop and the occupant posture angle are the most significant parameters in determining the lumbar spinal injury of occupant. It is observed that the injury criteria are directly proportional to the posture angle of the seat and height of drop.LncRNA (Long non-coding RNA) ZFAS1 (zinc finger antisense 1) functions as the oncogene in multiple cancers, including gastric cancer. However, its function and underlying mechanism in the GCA (gastric cardia adenocarcinoma), the most aggressive type of gastric cancer, remain unknown. We demonstrated here that the LncRNA ZFAS1 was up-regulated in GCA tissues. Furthermore, the elevated level of ZFAS1 was significantly associated with the GCA metastasis and cancer recurrence. It was also demonstrated to be an independent prognostic indicator of disease-free survival and overall survival for GCA patients. RNA sequencing showed that the up-regulated ZFAS1 was tightly associated with the down-regulated hypoxia inducible factor 1 (HIF1) and up-regulated EPAS1 (Endothelial PAS domain protein 1, also known as HIF2). In vitro studies showed that the ZFAS1 could bind to EPAS1, enhance its abilities to epigenetically silence the HIF1, and promote its own expression in GCA cell lines. In the animal model, co-delivering the EPAS1 and the ZFAS1 antisense oligos could significantly boost up their therapeutic effects on tumor growth. Thus, targeting ZFAS1 and EPAS1 might be an alternative therapeutic option in GCA.
The concentration of fluid and its analysis in human skin is innately a challenge due to its continuous movement and involvement in maximum life processes. The concentration of the fluid gets affected by the diffusion of fluids through the skin, which acts as the main barrier between the human body and the external environment. Therefore, it becomes imperative to study the process and impact of the diffusion of fluids through the skin. The problem becomes more interesting when the human body is immersed in water.
The present paper studies the change in the fluid distribution of human skin during its immersion in water of different temperatures. The application part of the paper visualizes various impaired vascular function and muscle soreness by water immersion during the physiotherapy treatment.
A mathematical model based on the two-dimensional diffusion equation, along with appropriate boundary conditions, has been formulated. The maximum of the relevant parameters, such as fluid regulation, transfer f the two processes. The paper has applications in water immersion therapies and other activities like monitoring swimming induced pulmonary edema, etc.
Femoral neck fractures in elderly patients needing oxygen therapy are often encountered in the emergency department. This single-center, retrospective, observational study aimed to examine the frequency, cause, and factors related to hypoxia in elderly patients with femoral neck fractures.
We analyzed data from 241 patients admitted to Okayama Saiseikai General Hospital (Okayama, Japan) from April 2016 to March 2019. Hypoxia was defined as PaO
/FiO
ratio under 300. The independent factors for hypoxia were determined by multiple logistic regression analysis.
There were 194 patients who met the study inclusion criteria, 148 in the non-hypoxia group and 46 in the hypoxia group. The hypoxia group included patients with pneumonia (
=3), chronic obstructive pulmonary disease (
=2), pulmonary edema (
=1), and pulmonary embolization (
=1). The cause of hypoxia was undetermined in 39 cases. However, occult fat embolism syndrome was suspected in 29 of these 39 cases based on Gurd and Wilson criteria after considering clinical examination results.Veliparib supplier
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