ll as specific training initiatives may be beneficial to broaden the application of L-RAMPS.Over the last decades, land management options have been investigated that aim at enhancing services to agriculture delivered by biodiversity and its associated biotic interactions. Such services can be promoted through land management strategies ranging from in-field single agricultural practices, long-term strategies compiling these agricultural practices at the crop rotation scale, to management strategies at the landscape scale. In this paper, we provide an overview of the land management options that can be implemented at multiple scales, with a specific focus on the provision of one service that is key in agriculture, i.e. pest control. We present existing knowledge and highlight current gaps and limitations in our understanding of pest control response to land management. Based on this analysis, we propose two promising and complementary research approaches that could help filling existing knowledge gaps and provide guidelines for designing landscapes for agroecological services (1) landscape monitoring networks (LMN), based on long-term monitoring of ecological and managerial processes within sets of landscapes located in contrasted production contexts; (2) agroecological system experiments (ASE), which design and assess combinations of land management options at multiple embedded spatial scales.
The COVID-19 pandemic is a heavy burden in terms of health care resources. Future decision-making policies require consistent data on the management and prognosis of the older patients (> 70years old) with COVID-19 admitted in the intensive care unit (ICU).
Characteristics, management, and prognosis of critically ill old patients (> 70years) were extracted from the international prospective COVID-ICU database. A propensity score weighted-comparison evaluated the impact of intubation upon admission on Day-90 mortality.
The analysis included 1199 (28% of the COVID-ICU cohort) patients (median [interquartile] age 74 [72-78] years). Fifty-three percent, 31%, and 16% were 70-74, 75-79, and over 80years old, respectively. The most frequent comorbidities were chronic hypertension (62%), diabetes (30%), and chronic respiratory disease (25%). Median Clinical Frailty Scale was 3 (2-3). Upon admission, the PaO
/FiO
ratio was 154 (105-222). 740 (62%) patients were intubated on Day-1 and eventually 938 (78%ICU admission.The plot-level decisions of land managers (i.e., farmers, ranchers, and forest owners) influence landscape-scale environmental outcomes for biodiversity in agricultural landscapes. The impacts of their decisions often develop in complex, non-additive ways that unfold over time and space. Behavioral science offers insights into ways decision-makers manage complexity, uncertainty, choice over time, and social influence. We review such insights to understand the plot-level conservation actions of farmers that impact biodiversity. To make these connections concrete, we provide a case study of the decision to adopt biodiversity management practices in the heavily cultivated region of the Central Valley, California, USA. We use results from a survey of 122 farmers in the region to test whether adoption is related to farm tenure arrangements or peer influence. We find farmers who are more sensitive to peer influence are three times more likely to adopt practices that support biodiversity, including wildflowers, native grasses, cover crops, hedgerows, and wetlands. This relationship could have important implications for how plot-level decisions aggregate to landscape-scale outcomes. Finally, we suggest priorities for future research and program design to integrate behavioral science into biodiversity conservation in agricultural landscapes. By considering land managers' plot-level conservation decisions with the lens of behavioral science, we identify barriers and opportunities to promote environmental benefits.Posttraumatic stress disorder (PTSD) is a severe mental disorder that can develop after a traumatic event. PTSD has been reported to be associated with activation of the innate immune system, as measured by increased levels of pro-inflammatory cytokines. While it is well known that PTSD patients display increased levels of interleukin 6 (IL-6) when compared with healthy controls, the relationship between cytokine secretion and treatment outcome has been hardly investigated yet. The aim of this study was to assess the potential association of inflammatory activation and therapy outcome in PTSD. learn more Before therapeutic intervention, we applied the Trier Social Stress Test (TSST) as a method to elicit psychosocial stress and an acute inflammatory response. IL-6 levels were measured in blood plasma of PTSD patients at different time points before and after the TSST. Severity of depressive, trauma-related, and somatic symptoms was assessed before and 8 weeks after trauma-focused treatment in a multimodal day clinic setting. We showed that high reactivity of IL-6 to psychosocial stress at the beginning of the therapy was associated with a negative therapy outcome in PTSD, especially regarding depressive symptoms. This study suggests plasma IL-6 reactivity as a potential molecular marker to predict treatment outcome in PTSD.
AP3B2 is one of the subunits of vesicle coat protein AP3 and is specifically expressed in central nervous system neurons. AP3B2 antibody has been reported in patients with autoimmune cerebellar ataxia and various extracerebellar symptoms. However, there have been few reports on its clinical features and treatment response.
We report a 47-year-old man with AP3B2 antibody who presented with insidious-onset paresthesia and gait disturbance. His serum and cerebrospinal fluid (CSF) showed reactivity with the cytoplasm of Purkinje cells and granular layer synapses comparable to the reported specific pattern of anti-AP3B2 IgG, and this was confirmed by a cell-based assay. His symptoms improved after the administration of intravenous immunoglobulin, and oral prednisone and mycophenolate mofetil. Extensive examination and long-term follow-up showed no evidence of malignancy. A literature review was included to emphasize the neurological syndrome associated with this rare autoantibody.
Eleven cases with AP3B2 antibody, including our patient, were identified.learn more
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