Determine how you want to be active, what kinds of things you want to Tweet about and then look for people that value the same things you do and follow them. It will take some trial and error, I followed a bunch of people at the beginning and then ended up unfollowing a few that really weren't putting out the kinds of messages I thought were beneficial.
Also, Twitter is great for really expanding your mind and exposing yourself to other viewpoints so try following some people you might not normally meet in real life, that will help you gain a more well-rounded perspective on things.
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Determine how you want to be active, what kinds of things you want to Tweet about and then look for people that value the same things you do and follow them. It will take some trial and error, I followed a bunch of people at the beginning and then ended up unfollowing a few that really weren't putting out the kinds of messages I thought were beneficial.
Also, Twitter is great for really expanding your mind and exposing yourself to other viewpoints so try following some people you might not normally meet in real life, that will help you gain a more well-rounded perspective on things.