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Paperium
Paperium

Posted on • Originally published at paperium.net

LLM4Cell: A Survey of Large Language and Agentic Models for Single-Cell Biology

How AI is Turning Single Cells into Storytellers

What if a computer could read the hidden language of every cell in your body? Researchers have uncovered that huge language‑model AIs are now being taught to understand the tiny data each cell carries.
The new LLM4Cell survey gathers almost 60 of these smart tools—think of them as multilingual translators that turn raw gene signals into clear, everyday words.
By linking RNA, DNA, and even spatial maps, the models can label cell types, track how they change over time, and even guess how a drug will affect them, much like a weather forecast predicts tomorrow’s rain.
This “AI‑cell” partnership means doctors could one day spot disease early or design personalized medicines faster than ever.
The biggest surprise? All this power comes from teaching computers to think in plain language, turning complex biology into a story we can all understand.
Imagine the possibilities when every cell’s whisper becomes a conversation we can hear.
It’s a breakthrough that brings science closer to home—and the future is already speaking.

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LLM4Cell: A Survey of Large Language and Agentic Models for Single-Cell Biology

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