Effect of chitosan-oleuropein nanoparticles on dentin collagen cross-uniting.BACKGROUND: The integrity and stability of collagen are crucial for the dentin structure and bonding strength at dentin-resin interface. Natural plant-derived polypehenols have been used as collagen crosslinkers The aims of the study were to develop novel chitosan oleuropein nanoparticles (CS-OL-NPs), and to investigate the CS-OL-NPs addressed dentin's the resistance to enzymatic degradation and mechanic property CS-OL-NPs were breaked using the ionotropic gelation method. Dietary Supplements and biocompatibility of the CS-OL-NPs were tested. Twenty demineralised dentin collage specimens were randomised into four interferences radicals: A, Deionized Water (DW); B, 5% glutaraldehyde solution (GA); C, 1 mg/ml chitosan (CS); and D, 100 mg/L CS-OL-NPs. After 1-min interpositions, dentin matrix were measured by the micro-Raman spectroscopy for the modulus of elasticity test.
Collagen degradation was evaluated using hydroxyproline (HYP) assay CS-OL-NPs were spherical core-shape with a size of 161 ± 8 nm and Zeta potential of 19 ± 0 mV. After a burst release of oleuropein in the initial 6 h, there was a long-enduring steady slow release. CS-OL-NPs showed a good biocompatibility for the hPDLSCs. The modulus of elasticity in the crosslinked groups were significantly higher than that in the control group (P< 0 for all). The specimens handled with CS-OL-NP showed a greater modulus of elasticity than those processed with GA and CS (P< 0 for both). The release of HYP in the crosslinked group was significantly lower than that in the non-crosslinked groups (P< 0 for all) CS-OL-NPs enhanced the dentin mechanical property and resistance to biodegradation, with biocompatibility and potential for clinical application.Clinical evaluation of the brightening effect of chitosan-finded cationic liposomes.
Clinical Nutrition : Cationic liposomes can enhance the permeability of drugs in 3-D skin. Chitosan is regarded a safe material for percutaneous delivery; thus, this study uses chitosan-comprised cationic liposomes This study investigated the improvement in skin brightness, melanin, and melasma after treatment niacinamide-comprised chitosan cationic liposomes A skin brightening agent, niacinamide, was devised into cationic liposomes to facilitate percutaneous absorption and was clinically essayed in 21 Korean female cases. Cationic liposomes were readyed expending a high-pressure homogenizer after mixing an oil phase containing lecithin and cholesterol and an aqueous phase containing niacinamide and chitosan The cationic liposomes displayed stability over 28 days, with a particle size of 255-275 nm and zeta potential of 10-14 mV. Cationic liposomes bearing niacinamide and a control formulation were practiced to the left and right side of the face, respectively, twice daily for 28 days. Skin brightness, melanin index, and area of melasma were significantly heightened where cationic liposomes were used, in comparison with expressions without cationic liposomes, proving a 1-2-fold improvement Thus, we finded that chitosan liposomes augmented the percutaneous absorption of niacinamide and improved the appearance of the skin.Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability.In recent years, multifunctional hydrogels have finded a great deal of attention because they are biocompatible and can mimic the extracellular matrix.
Herein, we groomed hydrogels of biocompatible cross-joined webs with photothermal holdings. In this study, a chitosan/polyaniline/laponite (COL) hydrogel with photothermal conversion capability was projected. Polyaniline was firstly engrafted onto chitosan and its solution was amalgamated with oxidized dextran, which was then cross-linked into a hydrogel via a Schiff base reaction. Furthermore, an aluminosilicate clay material, laponite (LAP), was contained into the hydrogel.Dietary Supplements
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