The Next-Generation Organoid Technology Paradigm
Traditional organoid models lack perfusable vasculature, functional immune systems, and efficient data analysis.
Xianjue Bio (Suzhou BioXGEN) has built China’s only integrated platform:
Vascularization + Immune Microenvironment + AI Closed Loop
Vascularized Microphysiological Technology
- Integrates 3D bioprinting and microfluidics to build perfusable functional microvascular networks.
- Uses proprietary peptide and extracellular matrix bionic hydrogel to promote vascular self-assembly.
- Vascular networks remain stable for more than 21 days.
- Recapitulates tumor–vascular crosstalk consistent with clinical pathology.
Immune Microenvironment Reconstruction
- Introduces patient-derived immune cells to simulate real tumor–immune interactions.
- Recapitulates lung cancer heterogeneity: vascularized clusters vs. non-vascularized spheres.
- Enables direct observation of PBMC infiltration and tumor cell apoptosis in anti–PD-1 treatment.
- Improves accuracy of immunotherapy drug screening.
AI-Powered Intelligent Analysis
- Multi-modal imaging: brightfield, fluorescence, digital confocal.
- 4D dynamic capture: temporal continuous observation + spatial 3D scanning.
- AI automatically quantifies cell number, area, morphology, circularity, etc.
- Supports 2D/3D reconstruction and automatic report generation.
- Forms a closed loop: Culture → Imaging → Analysis → Regulation. Integrated Applications
- Hospitals: Personalized drug sensitivity testing.
- Research Institutes: Custom disease models.
- Pharmaceutical Companies: Preclinical efficacy/toxicity testing, reducing animal studies. Xianjue Bio is a national high-tech enterprise with a full-chain system: biomaterials, chips, instruments, software, and services.
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