PyQt has been around for quite some time and is backed up by Riverbank Computing Limited. Still, when Nokia owned qt, they developed the Qt binding...
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What would you recommend to a beginner / intermediate Python programmer needing a fairly simple GUI, but without needing C++ knowledge? The QT WYSIWYG tool looks like a strong argument for using that. I've used EasyGUI for some quick and dirty apps I've made for my own use.
You can use the GUI tool, which takes care of most things. If not PyQt, could go for Tkinter. Downside of Tkinter is it doesn't have a native OS look.
There are some other frameworks like wxPython, pygtk, but they lack a really good WYSIWYG tool