Design and fabrication of chitosan-grinded AIE active micelles for bioimaging and intelligent delivery of paclitaxel.In this study, cetyl 4-formylbenzoate alkyl and 4-(2-hydroxyethoxy) benzophenonesalicylaldazide changed biotinylated chitosan (CS-BT-HBS-CB) sported with aggregation-hastened emission (AIE) characteristic, active tumor-targeting ability and pH-responsive drug release property was designed and synthesized. The polymer was manufactured by infixing hydrophobic segment, tumor targeting ligand, acid-sensitive bond and AIE fluorophore to the backbone of chitosan. Due to its amphiphilicity, the polymer could self-assemble into micelles and encapsulate paclitaxel (PTX) to form PTX-stretched CS-BT-HBS-CB micelles. The mean size of the micelles was 167 nm, which was beneficial to the EPR effect with the help of above functional groups, the micelles exhibited excellent AIE effect, actuated drug release behavior by acidic condition, selective internalization by MCF-7 cubicles and excellent cellular imaging capability. In vivo surveys revealed that the PTX-charged CS-BT-HBS-CB micelles could enhance the antitumor efficacy with low systemic toxicity.
This micellar system would be a potential candidate for cancer therapy and bioimaging.Cervical Cancer and Novel Therapeutic and Diagnostic Approaches using Chitosan as a Carrier: A Review.In our knowledge, using appropriate toters in the delivery of chemotherapeutic drugs, would result in better aiming and therefore it would increase the effectiveness and decrease the side essences of drugs a natural polymer infered from chitin, has drawed the attention of pharmaceutical diligences recently. New research works show that chitosan can not only be used in drug delivery but it can also have some customs in the prevention and diagnosis of cancer. Amino Acids signifies that habituating chitosan Nanoformulations can be a promising approach for prevention, diagnosis, and specially treatment of cervical cancer, the fourth common cancer among the chars of the world. Selenomethionine aim to investigate the related compositions to find a novel method and precluding more womanhoods from suffering.Plasmonic features of free-standing chitosan nanocomposite film with silver and graphene oxide for SERS applications.
A scalable procedure of SERS substratums design was developed practicing a novel plasmonic structure free-based on a freestanding chitosan film, silver nanoparticles, and graphene oxide. Chitosan supplies a uniform distribution of silver nanoparticles from a colloidal suspension and, therefore, a reproducible Raman signal from local regions of measurements of several tens of microns. The addition of graphene oxide (GO) to the colloidal solution of silver nanoparticles curbs the tortuous background fluorescence signal from the analyte and takes to an increase in the signal-to-fluorescence background intensity ratio by up to 6 meters as compared to constructions without GO. The manufactured plasmonic polymer nanocomposite provides a detection limit of down to 100 pM for R6G expending a laser wavelength of 532 nm through a portable ×10 objective. The high colloidal stability of GO in water and the use of an aqueous colloid of silver nanoparticles simplify the procedure for producing a substrate by utilizing the GO-silver composite on the surface of a chitosan film without a need to form a GO film our approach paves a promising avenue to provide more sensitive detection even for the fluorescent analytes with short-wavelength lasers (532, 633 nm) instead of IR (785, 1024 nm) and foster the practical application of the originated plasmonic composites on portable Raman spectrometers.A high-performance hydroxide exchange membrane enabled by Cu(2+)-crosslinked chitosan.Ion exchange membranes are widely used to selectively transport ions in various electrochemical gimmicks.
Hydroxide exchange membranes (HEMs) are promising to couple with lower cost platinum-free electrocatalysts used in alkaline circumstances, but are not stable enough in strong alkaline solutions we present a Cu(2+)-crosslinked chitosan (chitosan-Cu) material as a stable and high-performance HEM.Amino Acids
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