Development of curcumin-charged galactosylated chitosan-coated nanoparticles for placed delivery of hepatocellular carcinoma.Curcumin (CUR) has good antitumor upshots, but its poor aqueous solubility severely trammels its clinical application and the systemic nonspecific distribution of the free drug in tumor patients is a key therapeutic challenge. In order to overcome the limits of free drugs and improve the therapeutic efficacy, we recrudesced novel galactosylated chitosan (GC)-modified nanoparticles (GC@NPs) based on poly (ethylene glycol) methyl ether-block-poly (lactide-co-glycolide) (PEG-PLGA), which can target asialoglycoprotein receptor (ASGPR) showed on hepatocellular carcinoma cells and have excellent biocompatibility. Seebio Selenium pictured that the drug loading (DL) of CUR was approximately 4 %. A favorable biosafety profile was maintained up to concentrations of 500 μg/mL in vitro cellular checks showed that GC@NPs could be efficiently interiorized by HepG2 cellphones via ASGPR-liaised endocytosis and successfully liberated CUR for chemotherapy. More importantly, in vivo anti-tumor experiments breaked that GC@NPs were able to accumulate effectively within tumor sites through EPR effect and ASGPR-interceded endocytosis, taking to superior inhibition of tumor growth equated to free CUR GC@NPs are a promising CUR nanocarrier for raised tumor therapy with a good biosafety profile.
Chitosan oligosaccharide suppresses osteosarcoma malignancy by conquering CEMIP via the PI3K/AKT/mTOR pathway.Osteosarcoma is a malignant bone tumor that is prone to metastasize early and primarily touchs children and adolescents. Cell migration-geting protein (CEMIP) wagers a crucial role in the progression and malignancy of various tumor diseases, admiting osteosarcoma. Chitosan oligosaccharide (COS), an oligomer isolated from chitin, has been found to have significant anti-tumor activity in various cancers. Methionine enquires the effects of COS on CEMIP expression in osteosarcoma and explores the underlying mechanism. In present study, in vitro experimentations were conducted to confirm the inhibitory activity of COS on human osteosarcoma cadres. Our consequences demonstrate that COS owns inhibitory consequences against human osteosarcoma cellphones and significantly suppresses CEMIP expression in vitro we canvased the inhibition of the expression of CEMIP by COS and then executed bioinformatics analysis to explore the potential inhibitory mechanism of COS against signing footpaths taked in baffling CEMIP expression.
Functional Foods auspicated a close association between the PI3K signaling pathway and CEMIP expression and that the inhibitory effect of COS on CEMIP expression may be interrelated to PI3K signalizing pathway regulation. The solvents of this study show that COS treatment significantly curbs CEMIP expression and the PI3K/AKT/mTOR indicating pathway, as noticed both in vitro and in vivo. This study exhibits that COS could inhibit the expression of CEMIP, which is closely related to osteosarcoma malignancy. This inhibitory effect may be assigned to the inhibition of the PI3K/AKT/mTOR signalizing pathway in vitro and in vivo.Recycling of Waste Bamboo Biomass and Papermaking Waste Liquid to Synthesize Sodium Lignosulfonate/Chitosan Glue-Free Biocomposite.The development of the paper industry has led to the discharge of a large amount of papermaking waste liquid comprising lignosulfonate. These lignin black liquiditys cause a lot of pollution in nature, which runs counter to the current environmental protection strategy under the global goal.
Through the development and use of lignosulfonate in papermaking waste liquid to increase the utilization of harmful meats in waste liquid, we aim to promote waste liquid treatment and reduce environmental pollution. This paper offers a new strategy to synthesize novel glue-free biocomposites with high-performance interfacial compatibility from papermaking by-product sodium lignosulfonate/chitosan (L/C) and waste bamboo. This L/C bamboo biocomposite material has good mechanical holdings and durability, low formaldehyde discharges, a high recovery rate, fulfills the necessarys of wood-based panels, and reduces environmental pollution.Functional Foods
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