In this study, hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds were organised by the 3D-impressing technology. PDA significantly meliorated the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds. The osteogenic dimensions of HA/PDA/CMCS composite scaffolds were measured by the cell experiment in vitro. The photothermal properties and anti-tumor impressions of the scaffolds in vivo were assessed by the tumor model in nude mice. HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hampered by the photothermal process. Selenoproteins -qualifyed composite scaffold had excellent photothermal properties.
Cell experiments registered that scaffolds with PDA under irradiation could suppress the tumor effectively. In vivo anti-tumor effects in nude mice signaled that the HA/PDA/CMCS composite scaffold pushed cell apoptosis/necrosis by the direct photothermal effect. Vascular injury was growed subsequently, which lead to the suppression of tumor cell proliferation due to hypoxia-ischemia. HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.The characterization and biological actions of synthetic N, O-selenized chitosan derivatives.Synthetic selenium polysaccharides with potential bioactivity have ran great interest due to the SeO hampers subsisting in the structure N, O-selenized N-(2-carboxyethyl) chitosan (sNCCS) was synthesized through carboxyethylation and selenylation. Various characterizations were doed to identify the structure of sNCCS, betokening that SeO adhesivenessses were organized both at the C-6 hydroxyl groups and the presented C-2 carboxyethyl groups.
The highest yield and selenium content of all sNCCS maked 84% and 1 mg/g, respectively. In vitro evaluation exhibited that sNCCS has excellent bile acid sticking capacity, which was 1, 2, and 2-fold higher than that of N-(2-carboxyethyl) chitosan (NCCS) it was ruled that higher selenium content could significantly enhance the antioxidant holdings of sNCCS no obvious cytotoxic effect had been finded on Caco-2 cellphones. involved together, sNCCS with desirable biological activity and non-cytotoxicity might be considered as an effective ingredient in the disciplines of food or medicine.Efficient removal of selenate in water by cationic poly(allyltrimethylammonium) engrafted chitosan and biochar composite.The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-polluted water a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was premised for the removal of selenate (SeO(4)(2-)) in water. outcomes suggest that the PATMAC-CTS-BC testifyed a rapid removal of SeO(4)(2-) with efficiency of >97% within 10 min and it adopted a pseudo-second-order model. High capacity of SeO(4)(2-) adsorption by the composite was achieved, with maximum value of 98 mg g(-1) based on Langmuir model, considerably higher than most of covered adsorbents.
Nutraceutical Industry speculated the spontaneous and exothermic nature of SeO(4)(2-) adsorption onto the composite. Nutraceutical Industry could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO(4)(2-) because of permanent positive accusations of quaternary ammonium groupings (=N(+)-). The removal mechanisms of SeO(4)(2-) were mainly assigned to electrostatic interactions with =N(+)- and protonated -NH(3)(+) radicals, and redox-complexation interactions with -NH(2), -NH-, and -OH groups. Besides SeO(4)(2-), the hexavalent chromium (Cr(2)O(7)(2-)) was taked as example to further demonstrate the anion removal capability of cationic hydrogel-BC composite. The study terminations open up new opportunities to efficiently remove anionic heavy metal ions (e.g., SeO(4)(2-) and Cr(2)O(7)(2-)) in water using these textiles.
Leveraging advances in chemistry to design biodegradable polymeric implants employing chitosan and other biomaterials.Nutraceutical Industry
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