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🔬 Research Gap Report: Schizophrenia

#research #science #openscience #medicine

🔬 Research Gap Report: Schizophrenia

Generated: 2026-02-04 | KRISTAL PATHFINDER

📊 Scan Summary

Metric Count
Papers Analyzed 24
Clinical Trials 20
Research Gaps 7
Recruiting Trials 3

🕳️ Critical Research Gaps

⚠️ Longitudinal Data Deficit

No studies address long-term outcomes or disease progression tracking for Schizophrenia. Natural history models and treatment durability remain unknown.

Category: Temporal

Tags: longitudinal follow-up natural-history

⚠️ Diversity & Equity Gap

No studies address racial/ethnic disparities. Findings may not generalize across demographics.

Category: Population

Tags: diversity equity DEI

⚠️ Pediatric Population Gap

No studies address pediatric or adolescent populations. Age-specific manifestations and dosing are unknown.

Category: Population

Tags: pediatric age-specific

⚡ Medium Priority Gaps

  • Comorbidity Blindspot: Comorbid conditions and their impact on Schizophrenia treatment response are not addressed.
  • Health Economics Gap: No cost-effectiveness or health economics data found. Payer decision-making barriers remain unaddressed.
  • Patient-Reported Outcomes Missing: No PROMs or quality of life measures found. The patient experience perspective is absent.
  • Real-World Evidence Gap: No real-world evidence or post-marketing studies found. Effectiveness outside trial settings is unknown.

🧪 Trial Landscape

  • Recruiting: 3 trials actively enrolling
  • Total Found: 20 trials
  • Phases: NA, PHASE1, PHASE4, Not specified, PHASE3

Currently Recruiting

  • NCT06993662 — The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under ...
  • NCT05208190 — Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical...
  • NCT04529226 — Study to Compare Clozapine vs Treatment as Usual in People With Intellectual Dis...

📚 Key Papers (Sample)

  • Schizophrenia: from neurochemistry to circuits, symptoms and treatments. (2024) — PubMed
  • Glutamatergic dysfunction in Schizophrenia. (2022) — PubMed
  • Schizophrenia. (2025) — PubMed
  • Post-traumatic Stress Disorder. (2023) — PubMed
  • What is the neurobiology of schizophrenia? (2024) — PubMed

⚠️ Disclaimer

This report is for research organization only. Not for clinical decision-making, diagnosis, or treatment. All content requires expert review and validation.

🔬 About This Tool

KRISTAL PATHFINDER — Disease Gap Intelligence

Created by Mullair Jeudi MD • Kristal Labs

Free for researchers worldwide. No accounts, no paywalls, no data collection.

MIT License • 2025

If this report helped your research, please cite:

Jeudi, M. (2025). Kristal Pathfinder: Disease Gap Intelligence Tool. GitHub. https://github.com/mullairj/kristal-pathfinder

This report was automatically generated by the Pathfinder Daemon.

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