Is there a compatibility issue with Postgres and python UUID ?

Am regularly receiving a 500 error in my Django backend on AWS, and the message is "UUID is not a valid UUID", and it's raised by a Validation error.

The weird about this is, i just have to restart the server and everything continue to work without problem. But sometime it crash, and i am not able to know what cause this.

This issue is the same explained here: https://code.djangoproject.com/ticket/29293

Am only having this in production.

Hope someone has face and resolve the similar issue in the past.

Thanks