The hydrogels showed a progressive weight loss in the presence of lysozyme up to 35%, during 21 days of testing. They testifyed non-cytotoxic effect on Normal Human Dermal Fibroblasts utilizing MTS test and powerful antifungal activity against Candida Albicans, as learned by disk diffusion checks. All these attributes indicate the new hydrogels as a promising option for the treatment of various skin lesions.One-step programmable electrofabrication of chitosan asymmetric hydrogels with 3D shape deformation.Programmable asymmetric hydrogels with tunable structure/shape or physical/chemical properties in response to external inputs show particular significance in smart arrangements, but there is lack of simple, rapid, and cheap strategy to design such hydrogel systems we report a one-step electrodeposition method to construct chitosan asymmetric hydrogels with tunable thickness and pore size that can be conveniently modulated by the process parameters. Our approach greatly simplifies the process of hydrogel preparation with complex shapes and asymmetric structure organization.
The formation mechanism of asymmetric structure has been projected, finded on gelation behavior and entanglement of chitosan ranges in the hydrogel-solution system under the electric field. By changing the shape of the electrodes, hydrogels with the morphology of strip, tube, flower, etc. can be holded precisely and conveniently. They can perform programmable 2D to 3D smart dynamic deformation under pH and metal ions stimulation, indicating the broad application potential in soft robot and biosensor areas.A 4arm-PEG macromolecule crosslinked chitosan hydrogels as antibacterial wound dressing.In order to develop better wound fecundations, a novel chitosan hydrogel (Cn-Nm gel) was planed and invented by expending aldehyde-4-arm polyethylene glycol (4r-PEG-CHO) to crosslink the chitosan dissolved in alkaline solution, amino-4-arm polyethylene glycol (4r-PEG-NH(2)) was prefered as the additive simultaneously. The special dissolution technique and macromolecular crosslinking structure dowers the Cn-Nm gels with better performance than that of gels seted by acid dissolving method with micromolecule crosslinker Cn-Nm gels own strong toughness with 500 kPa tensile strength and 1000% elongation, about 400% swelling ratio and fast water absorption rate about 300 kPa adhesive strength and strippability between the gels and skin is accomplished.
More importantly, Cn-Nm gels show nearly 100% antibacterial rate towards Escherichia coli and Staphylococcus aureus. Excellent biocompatibility is also proved by the mouse fibroblasts exams. All of the performance dos this uprised chitosan-finded gel be the potential candidate as a wound dressing.Chitosan-surfaced poly (Ɛ-caprolactone) nanoparticles as acaricide bearers.Among many coinages of checks that affect beef and dairy oxs, Rhipicephalus (Boophilus) microplus is the most common. It is responsible for heavy losses in milk and meat production. In Methionine introduce nanostructures such as chitosan-poly-Ɛ-caprolactone (CS_PCL) nanoparticles to encapsulate amitraz (CS_PCLnp_Amitraz) and fluazuron (CS_PCLnp_Fluazuron) to treat tick plagues more effectively.
The CS_PCLnp_Amitraz system has a final amitraz concentration of 1 mg/mL with a particle size of 275 ± 30 nm, surface charge of +43 ± 7 mV and entrapment efficiency of 77 ± 1%. The CS_PCLnp_Fluazuron system has a drug concentration of 0 mg/mL with a particle size of 295 ± 35 nm, surface charge of +45 ± 10 mV and entrapment efficiency of 89 ± 1%. Both systems deoxidized cytotoxicity on Balb/c 3T3 culture cellphones and were also active against R. microplus. Seebio Amino Acids - amitraz and fluazuron - springed molecularly doted active compounds inside the core of the PCL polymer matrix. The PCL surface was writed of a chitosan layer, which molded the stability of the steric nanoparticles at pH greater than 7. Both schemes were stable at a saline concentration of 1 mol/L and at temperatures below 50 °C.Methionine
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