I've found PySimpleGUI to be a great platform for quickly building a desktop app. Everything I've built with it is small (I.e. not an enterprise application,) so take my evaluation with a grain of salt- but my experiences have all been fantastic. My only real gripe is their readthedocs page is a bit of a mess.
This, to all points. Small application, simple GUI development, but the docs are a mess.
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