How can we effectively combine Go, TypeScript, Python, and WebGL in a single application?

I’ve been thinking about how different programming languages shine in their own areas:

• Python is perfect for scientific computation, machine learning, and quick prototyping.
• TypeScript dominates when building rich web or desktop apps (and has great tooling through VS Code).
• Go is excellent for backend services, concurrency, and deployment speed.
• WebGL (via JavaScript or TypeScript) makes it possible to render interactive graphics and video directly in the browser.

Each of these ecosystems is powerful on its own — but real-world applications often need the strengths of several. For example:

• Using Python for AI model inference,
• Go to handle fast concurrent servers,
• TypeScript/WebGL for an interactive front end.

So here’s the core question:

What are effective modern strategies, tools, or architectures for connecting these languages together in one cohesive project?

I have a few ideas, but I’d love to get insights from others who’ve built multi-language systems:

• Should something like gRPC/Protobuf be the glue between Go and Python?
• Can we use WebAssembly (WASM) to share logic between browser and backend?
• What about using message queues (e.g., Redis, Kafka) for structured language-agnostic communication?
• Are there practical workflows to make multi-language development not a maintenance nightmare?

Any examples, open-source frameworks, or architectural patterns would be really helpful.