How to Connect Python to the Ethereum Sepolia Testnet Using Web3.py

Connecting Python applications to smart contracts allows you to build tamper-proof logging pipelines. Here is a quick, step-by-step guide to sending data to the Sepolia testnet using Web3.py.

Prerequisites

• Python 3.8+ installed
• An RPC URL (from Infura or Alchemy)
• A Sepolia testnet wallet address & private key

Step 1: Install Web3.py

pip install web3

Step 2: Initialize the Connection

from web3 import Web3

• Connect to Sepolia via Infura w3 = Web3(Web3.HTTPProvider('YOUR_INFURA_SEPOLIA_URL'))

if w3.is_connected():
print("Successfully connected to Sepolia Testnet!")
else:
print("Connection failed.")

Step 3: Call Your Smart Contract

• Define contract address and ABI, then send transaction...