I'm a righty what are you? Well chances are your one of two left or right handed. So it must be a pain when a website is geared towards the opposite hand. Sure there must be coping strategies, but what if you could detect a user's handedness.
The question might be a matter of who is responsible for this detection or storage of preferences, say chrome for example. Why can't I save a preference that a js API has exposure too? Regardless, it's probably not going to happen any time soon.
I put it to you, perhaps as a challenge? Design an algorithm for the web that uses mobile sensors or maybe touch detection to semi accurately figure out which hand you are using.
I'd love to see what you have come up with.