Flask is among the most minimalist web frameworks available for Python. Django has more features (or bloat, depending on your view point). It comes with an Object Relational Manager (ORM) and many more features.
You can easily put it online using a service like PythonAnywhere. In just a few clicks, your Python app is online
If you developed for the web before, you may wonder why not use PHP or another programming language?
Python lets you build apps very quickly and you don't have to worry to much about extensibility.
Modules can be used in Python and there are way more available for Python than for instance PHP.
Fair you say, but I only need CRUD databases?
Even considering that you only use the same basics (like with Laravel), the Python syntax is a lot cleaner than PHP.
The web is available on all platforms and devices. In the early 90s desktop apps were all the rage, but these days lots of people use mobile devices.
Mobile internet users overtook desktop users a few years ago:
Yes, the desktop is still around. But mostly for developers and office workers. People spend lots of time on the web (and mobile).
But regardless of device, if you have a web browser then web apps always work. Though you might need to optimize for the browser and responsiveness.