In 2024, the Nobel Prize in Chemistry recognized Baker for computational protein design, and Demis Hassabis and John Jumper for protein structure prediction…
De novo: no natural protein used as the starting point. Generative AI design: deep-learning models such as RFdiffusion or ESM3 that generate new proteins. Case 2: Snake venom, with fine print A 2025 Nature paper reported proteins designed to bind three-finger toxins.
Key takeaways
- Case 6: NL-201, the sobering one Neoleukin believed NL-201 was the first fully de novo protein evaluated in clinical trials.
- Some binders are becoming tractable to design.
- The one approved vaccine was designed using earlier methods.
Bennett et al., de novo antibodies, Nature 649:183–193: PubMed; structures 9NH7, 9NFU 4.
Read the full article: https://www.futurenow.click/ai-designed-proteins/
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