I'am a Django developer, and I really love this framework, specially the Django-ORM. But, I've been discarding several parts of Django for years.
I completely eliminated the use of the template system, and practically Django has stayed only to create WEB APIs (Django REST Framework, and now Graphene/GraphQL).
Basically, a ORM (I take a look to Sequelize and Waterline) and Controller framework (I take a look to Express.js and Sails). The idea is to find something that also gets along well with GraphQL.
We use Vue on the frontend.
What do you think? Node is a new world for me.